Friday, August 31, 2012

PFT: Do Giants have new 1-2 backfield punch?

tom-brady-1Getty Images

With less than a week to go until the ball flies end over end through the New Jersey twilight (unless the team tries to make the replacement officials? heads implode by attempting an onside kick), the NFL has announced that new rules will apply in 2012 for the trade deadline and injured reserve.

The easy part relates to the trade deadline.? It has been moved from October 16 to October 30.? So instead of the Tuesday after Week Six, trades must happen by 4:00 p.m. ET on the Tuesday after Week Eight.

The injured reserve rule allows one player per team to be activated from IR after a ?major injury.?? The player must miss at least six weeks of practice.? He may be placed on the active list at least eight weeks after placement on injured reserve.

Unlike the PUP list, then, the window for returning to practice or returning to action doesn?t close.? Once it?s open, it stays open.

Patriots owner Robert Kraft has said that, if such a provision had been in place four years ago, the team possibly would have used the designation for quarterback Tom Brady, who tore an ACL in Week One.

Here?s where it gets complicated.? Because teams already have cut to 75, a special procedure applies for 2012.? As to teams that already have placed players on IR, the player for whom the short-term IR procedure will be used must be placed back on the active roster by 9:00 p.m. ET, August 31.? He?ll then count as one of the final 53.

Then, after 4:00 p.m. ET on Tuesday, September 4, each team can place one player on the modified IR list.

This means that teams hoping to use the new IR rule for a player already on injured reserve will have to displace another player for nearly four days, using a roster spot for the injured player and then creating a roster spot next Tuesday, when that player goes back to IR.

Confused?? Good.? Because it took me an hour to figure it out.

It will take far less than an hour for you to check out a slice of PFT Live regarding the looming roster reductions, along with admittedly rank speculation about a couple of possible surprise moves.

Source: http://profootballtalk.nbcsports.com/2012/08/29/bradshaw-wilson-could-be-inside-outside-combo-for-giants/related

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Thursday, August 30, 2012

Things You Should Know About Email Marketing | Internet Marketing ...

There are a lot of myths about online marketing. Now a few misconceptions may not matter all that much if they were harmless, but when it comes to your money, then it?s always better to be well-informed. Some of the worst, most damaging myths out there revolve around business to business email marketing. With that in mind, here are some things you should be aware of before running your next email campaign.

1. Know your customer. The more you know about your customer, the better. What are their problems? What are their current solutions? How can you help them? What do you know about their business? All of these questions need to be answered before you send a company an email message. First, you need to make sure they are a good customer for your offer. Second, it shows respect and they will appreciate that you know something about who they are.

2. Get to the point. Imagine you are meeting with your prospective customer at their place of business. You may start with a bit of small talk, but you wouldn?t linger on it. In other words, you can start your business to business email marketing with a friendly tone, but you also have to stick with a no-nonsense approach at the same time.

3. Remember who the message is for. Yes, you are sending out the email to generate profits for your own business, but the message it contains is for the person receiving it. In other words, you have to be very clear about how your offer benefits them.

4. Ask for their business. One of the biggest mistakes people make when it comes to business to business email marketing is not being bold enough in closing the deal. You don?t have the benefit of making your presentation in a face-to-face setting, so you need to be clear and direct in what you want the reader of your message to do.

5. Don?t use trickery to get them to open your email. Sure, you may get them to open your message, but you will have done so through dishonesty. That will kill the sale before you ever get a chance to present your offer. You also need to bear in mind that there is a fine line between being clever and being deceitful; make sure you don?t cross it.

6. Track results. When doing business to business email marketing you should keep track of and measure everything you can. When you sent out each message, to whom, what the subject line was, the body of the email, open rates, click-through rates, how many previous messages you have sent, and so on. You can use any and all of this data to refine your sales message and improve your results over time.

In today?s world, mastering the art and science of business to business email marketing is one of the most important keys to success. It?s relatively inexpensive, especially when compared to traditional forms of advertising, and it can give you a very robust return on your investment.

Source: http://jagwealth.com/things-you-should-know-about-email-marketing/

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Sony Pumps Up Mobile Lineup With New Xperia T, V, And J Smartphones

6_sony_logo_wAfter a bit of on-stage patter in Berlin, Sony CEO Kazuo Hirai officially pulled back the curtains on a slew of new Xperia handsets -- the Xperias T, V, and J. The Xperia T (previously known as the Mint) is the clear standout in this crowd with its 4.6 inch display, which also takes advantage of the company's Mobile Bravia Engine to produce to eye-popping (some would say "lurid") visuals. As previously reported, the flagship Xperia T also packs NFC and a 13-megapixel camera, which Hirai says can quickly go from sleep mode to snapping shots.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/iFgDk3mU5Pk/

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Wednesday, August 29, 2012

Zaza Raw, Organic Desserts ? Grace(full)Plate

I met Elisabeth Saucier of Zaza Raw at a 4th of July party up in the mountains and she was sweetly offering sweet morsels (as I like to call little desserts, that hit the sweet spot perfectly) to guests.

I was intrigued by Elisebeth?s story (Zaza was her nickname growing up) and loved how she was offering a dessert that was still delectable but was gluten-free, raw, organic and dairy-free. Not to mention, supporting local is a favorite of mine as she is based out of Boulder.

Elisabeth?s children were experiencing reactions and allergies to food and she felt inclined to offer something that her children could enjoy (and others with similar allergies) without having them feel like they couldn?t indulge in anything. In her own words:

Once we identified and eliminated gluten, soy and dairy my kids and I needed to figure out how to navigate the daily challenges of a specialized diet.

I wanted my kids to be able to go to a friend?s birthday party and share the joy of cupcakes and other desserts.

When I discovered that raw food was gluten free, dairy free and amazingly good I began creating kid friendly vegan, raw desserts.

I spent a few years challenging myself to create healthier and more interesting raw desserts.

In the spring 2011, I started Zaza Raw to make raw, uncooked dessert available to others.

Elisabeth gave me some of her desserts to try for myself.

I loved these raw coco-nut squares. These are dairy free, soy free and gluten free. They have a base of pecans, walnuts, raisins, dry coconut, raw cacao and raw agave nectar. The texture was soft and smooth and the coconut really came forward as the predominant taste.

As you can see, I could barely contain myself while I shared some of these goodies with co-workers and we didn?t even make it to plating the dessert.

The Raw Chocolate Ganache in particular, was the one that tasted the least like it didn?t have gluten or dairy (if both those ingredients are your thing and you?re skeptical, try that one).

I love that Elisabeth is not only helping guide her children?s plight in food allergies, while still enjoying delicious food, but also for everyone else around her. It?s such a delight to try and experiment with food even if you don?t have an intolerance, I encourage you try to her desserts.

In Mid-September, Elisabeth is working on some new changes aesthetically to her brand but also with some of the desserts. You can expect to see a raw brownie (I tried these, they were my favorite out of the whole bunch!) and even more chocolate, in the chocolate cheesecake. Be on the lookout!

Find Them:

You can find Zaza Raw at Whole Foods Market through the Rocky Mountain Region, Alfalfas (Boulder), Bodywork Bistro (Boulder) and Rally Sports (Boulder).

http://zazaraw.com/ | Facebook.com/ZaZaRaw | @ZaZaRaw

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Source: http://gracefullplate.com/zaza-raw-organic-desserts/

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Facebook is mishandling its crisis, experts say

Jim Urquhart / Reuters

Here I am! Wall Street is wondering where Facebook Apple Chief Executive Officer Mark Zuckerberg is as its stock languishes at half its debut price. PR experts say he needs to show leadership or find someone who will.

By Roland Jones, NBC News

?Where is Mark Zuckerberg?

The question was posed rather forcefully by CNBC host Jim Cramer last week as the social network?s share price continued to plunge and news broke that an early Facebook investor, Peter Thiel, had sold $400 million worth of stock in the company.

The drop in the value of Facebook since May has caused huge concern about the company on Wall Street, and media outlets have even called for the resignation of the company?s founder and CEO Mark Zuckerberg. Facebook shares were trading at around $19 recently, about half?their $38 price when they went public on May 18.

Cramer?s query echoes a broader feeling on Wall Street about the problems now bedeviling the popular social networking company: With the value of its shares down over 50 percent since its highly anticipated IPO, is the company making a hash of the public relations disaster it is now facing; and, just as important,?why has Zuckerberg remained quiet about the state of the company?

Facebook is in crisis, and in a crisis a company?s CEO should be front and center, acknowledging the key issues, apologizing to those affected and giving a commitment to not letting an incident happen again, said Larry Chiagouris, a marketing professor at Pace University?s Lubin School of Business.

?The company needs to make the investment community comfortable that it has people at the top that are serious and determined to make profits,? he said.

?The wonderful thing about the stock market is, in the final analysis, the price of something tends to move toward its real value, so if there really is value in Facebook beyond its current price, the management team has failed to communicate that to investors effectively,? Chiagouris added.

Increasingly, investors are asking if Facebook?s problems are more profound than simply a swooning stock price.

Technical glitches marred Facebook?s first day of trading on the Nasdaq stock market in May, leading to complaints of slow order confirmations and too many shares offered at too high a price. Lawsuits against Facebook and its underwriting banks followed, and Facebook?s share price hasn?t traded anywhere near its $38 offering price since then.

Facebook?s IPO was expected to be one of the biggest stock offerings to ever hit Wall Street, and the company?s offer price?valued the company at $104.2 billion, making it the largest company to go public in the U.S. by market capitalization.

Investors? love for Facebook drove interest in its IPO to extreme levels, and the same herd mentality is now working in reverse, said Chiagouris.

?[Facebook?s stock price] will eventually get to a point where its valuation is unrealistic,? he said. ?To turn that decline around, Facebook has to do a major move -- one would be to replace top management.?

While Mark Zuckerberg is clearly inventive, no one will ever say that he is an effective businessman, Chiagouris said. The company needs to turn the reins over to people who are ?adult? and not beholden to Zuckerberg, he added.

?Facebook has one thing that people want: The largest community in the world. That?s a wonderful asset, but they?re sitting on that asset and they haven?t figured out how to monetize it yet,? Chiagouris said. ?Facebook needs people who are savvy at monetizing an asset, and that would probably not include most of the top managers who are there now.?

Facebook?s Chief Operating Officer Sheryl Sandberg has long been seen on Wall Street as Facebook?s ?adult? executive, having spent years as a senior executive at Google. But Sandberg has yet to demonstrate any independence at the company, Chiagouris said, and despite her appointment to Facebook's seven-person board last June the company?s stock price has continued to slide.

When it comes to handling a crisis, Facebook?s management team has done a poor job, public relations experts say.

As a social media company, Facebook?s image is its most vital asset, said Mario Almonte is a partner at a New York-based Herman & Almonte Public Relations.

?Once MySpace lost its image, it lost its cool factor,? Almonte said. In the same way, Facebook is having an image problem, and this time it?s with Wall Street investors.

The main problem is Zuckerberg, Almonte said.

?He?s locking himself in a room somewhere and refusing to talk to anyone,? he said. ?I think he needs to swallow his pride and bring in experienced people who understand Wall Street and understand the nature of investing and the politics of Wall Street, because a lot of this is about perception.?

?Zuckerberg needs to step up to the microphone and assure them he is working on a strategy to make Facebook profitable for them - and then he must bring in better financial and marketing experts than himself to develop a clear strategy for transforming Facebook into a profitable enterprise,? he added.

Investors have grown skeptical of the company?s ability to communicate its plan to reverse slowing revenue growth and make money from mobile devices -- a channel of strong user growth.

Google is an example of a technology company that got its advertising business right, Almonte said, because ?the advertising is there, all around the user, but it never gets in the way of the clean, efficient user experience.?

?

?

"If people had known that [Peter] Thiel would be unloading stock, obviously they wouldn't be buying stock," says Jim Cramer. "Where's the outrage?"

Source: http://marketday.nbcnews.com/_news/2012/08/24/13460329-facebook-mishandling-its-crisis-experts-say?lite

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AFFTA's Government Affairs & Alliances Update | Angling Trade

From AFFTA:

AFFTA, through its Government Affairs & Alliances Committee, advocates on behalf of its members, keeping watch on legislation, regulations and policies that significantly affect our members? business and the sport of fly-fishing itself.

The following report on government affairs activity was prepared for and shared at the IFTD show last week.

Legislative Update
1.? Transportation Bill ? Jeff More, AFFTA?s Legislative Advocate, reports that there were two significant conservation victories in the Transportation Bill that was signed into law, full funding of the Sport Fish Restoration and Recreational Boating Safety Act and the inclusion of the RESTORE Act. The Sportfish Restoration Trust Fund will provide several hundred million dollars for fish habitat, water quality improvement and boating access across the nation and the Restore Act will provide several billion dollars for habitat restoration along the Gulf Coast over the next decade.

2.? Farm Bill ? Critical water quality improvement measures were included in the Senate Passed Farm Bill. The Farm Bill faces some significant hurdles in the House. During meetings with senior staff on the House Ag Committee last week, Jeff was informed that water quality improvement language should be in the final Farm Bill that goes to the President.

3.? Tax Incentive ? Jeff has been exploring the prospects for legislation that establishes a Fly Fishing in the Schools Program that would provide a tax incentive for manufacturers that donate fly fishing equipment to schools.

Outreach, Education and Alliances
AFFTA representatives participated in the following efforts:
1.? Protecting Bristol Bay ? The watershed is home to world-class salmon runs and a treasured fishing destination. AFFTA Board Members, Jim Klug, Larry Barrett and Andrew Bennett attended and presented comments at a hearing held by the EPA in Seattle to gather public comments on its draft watershed assessment of Bristol Bay. AFFTA supports protections for Bristol Bay thru the 404c process of the Clean Water Act.
Link: http://www.savebristolbay.org/blog/seattle-packs-epa-hearing-says-no-to-pebble-mine-june-1-2012

2.? White House Blog ? AFFTA was given the opportunity to write a guest post on the White House Blog. Ben?s post: Growing Our Economy Through the Great Outdoors highlighted the importance of the outdoor recreation economy and the Land and Water Conservation Fund. The blog post has been widely circulated in the fly fishing and conservation communities.
LINK: http://www.whitehouse.gov/blog/2012/07/31/growing-our-economy-through-great-outdoors

3.? Fishing, Hunting and Shooting Industry Op-Ed ? The Denver Post ran an Op-Ed pointing out the importance of the outdoor recreation economy and the contributions the fishing and hunting industry makes to conservation and the economy. The Op-Ed ran under Ben?s by-line and was co-authored by Jay McAninch of the Archery Trade Association, Mike Nussman of the American Sport Fishing Association, Thom Dammrich of the National Marine Manufacturers Association and Steve Sanetti of the National Shooting Sports Foundation.
LINK: http://www.denverpost.com/opinion/ci_21167304/guest-commentary-investing-outdoors.

4.? National Fisheries Friends Partnership?s Policy Roundtable
NFFP was established to help unite leading conservation, industry, business, and water-based recreation groups in a unique coalition to create and successfully advance a shared national agenda to conserve aquatic life and their habitats. Tom Sadler, an NFFP Board member, chaired a policy roundtable meeting to develop a consensus agenda for aquatic resource conservation. The first meeting yielded draft set of issues. Future meetings will fine-tune the list. Ben is representing AFFTA on the NFFP Roundtable.

5.? Sport Fishing and Boating Partnership Council?s Recommendations for Vision and Strategic Plan for USFWS Fisheries Program
In June the SFBPC began a process to make recommendations to the USFWS Fisheries program for updates to the program?s strategic plan. SFBPC created a steering committee of SFBPC members and stakeholder community leaders. Tom Sadler is representing AFFTA on the Steering Committee.

6.? Outdoor Industry Association?s Outdoor Recreation Coalition
OIA has been begun conversations on a new set of recreation policy asks that will garner the support of a broad and powerful recreation industry voice and is convening a group of industry leaders in DC to discuss this concept and define specific asks for the next administration and 113th Congress. Tom is representing AFFTA on the coalition.

7. Statements of Support
AFFTA adds the weight of its membership to advocacy efforts when they align with our mission. In 2012 we have added our voice to the following:
? Supporting the Public Lands Renewable Energy Development Act
? Supporting a strong Conservation Title in the Farm Bill
? Supporting water quality improvement provisions in the Farm Bill
? Supporting the Sportsmen?s Act as part of the Farm Bill.
? Comments on EPA?s Bristol Bay Watershed Assessment
? Statement of Support for the LWCF provision in the Senate Transportation bill.
? Supporting an amendment to the House Energy and Water Appropriations bill allowing the Army Corps of Engineers to finalize and implement Clean Water Act guidance.
? Expressing appreciation for a hearing on H.R. 3365, the Federal Land Transaction Facilitation Act Reauthorization
? Supporting Sod Saver provisions in the House Farm Bill
? Supporting Sod Saver provisions in the Senate Farm Bill
? Supporting RESTORE Act and LWCF provisions in Highway Bill
? Supporting Farm Bill Conservation Title
? Opposing Legislation blocking EPA Guidance on CWA jurisdiction
? Supporting the recommendations of the National Commission on the Deepwater Horizon Oil Spill that funds from penalties be dedicated to Gulf restoration and recovery.

Source: http://www.anglingtrade.com/2012/08/29/afftas-government-affairs-alliances-update/

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Tuesday, August 28, 2012

Antiques Valuaton Event ? Robocap

Antiques experts from a leading fine art auction house are encouraging people living in the Hereford area to search their attics and storerooms for forgotten treasures that might be worth a fortune.

Fine art director Jeremy Lamond will lead a team of experts from Shrewsbury-based Halls who have agreed to hold a charity antiques valuation event at Hereford Racecourse from 10.30am to 2.30pm on Friday, October 12 in association with the city?s mayor, Councillor Brian Wilcox.

All money raised from the event will go to the Mayor of Hereford chosen charities, The Haven and ROBOCAP.

Hereford Racecourse has agreed to host the antiques valuation event free of charge to support fundraising for the two charities.

A team of four experts from Halls will be available to value ceramics, furniture, works of art, paintings, silver, toys, books, militaria, sporting items and textiles in return for a ?2 fee for each item, with all the proceeds going to The Haven and ROBOCAP.

With centres in London, Leeds and Hereford, The Haven is the only national breast cancer charity that provides one-to-one support to improve the quality of life of anyone affected by breast cancer.

The Haven?s programme of care costs around ?1,000 to deliver to each visitor and the charity relies on donations of individuals and organisations to deliver its services. Since opening in 2004, The Hereford Haven has arranged more than 23,000 appointments and helped almost 2,000 visitors.
ROBOCAP is a charity aimed at providing ?Robotics Assisted Surgery? for men suffering from prostate cancer in the three shires of Gloucestershire, Herefordshire and South Worcestershire. In excess of 800 men a year are diagnosed with prostate cancer in the three shires.

Mr Lamond appealed to the people of Hereford and surrounding area to turn out to support the fundraising event for such good causes.

?This valuation event provides an ideal opportunity for people to have their family heirlooms and treasured items valued,? he said. ?If they have items that are too big to bring along on the day, they can simply show us photographs or we will be happy to arrange home visits after the event at no additional charge.

?In the past, we have discovered many valuable items in the Hereford area that have been stored away. What makes our job exciting is the possibility of discovering a long forgotten treasure that may have been passed down through the family and has never been valued.?
Halls are now accepting entries for an equestrian and sporting auction on November 7, an antique furniture, ceramics, clocks and works of art auction on November 21, a collective auction on December 5 and a busy programme of auction in 2013, when the company will move to a new multi-million headquarters and fine art auction centre.

For more information about the valuation event, contact Halls on Tel: 01743 284777, The Haven on 01432 361061, ROBOCAP on 01531 631898 or the Mayor of Hereford?s office on 01432 260438.

?

For more information please contact Mr Jeremy Lamond, Halls? fine art director, on 01743 284777 or Duncan Foulkes, public relations adviser, on 01686 650818.

Source: http://www.robocap.org.uk/robocap-news/antiques-experts-in-hereford-for-charity-valuation-event-for-robocap-and-the-haven/

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Construction company Orange County - Modern, Innovative ...

by Eternity Construction, Inc.

to Eternity Construction, Inc.

Home remodeling is one of the most common ways to quickly and affordably enhance the beauty of a home, without all of the drawbacks of purchasing an entirely new property. Many people consider this a better option than construction of a new house, because it is far more cost-effective and much less disruptive. If you are settled in Los Angeles and planning to renovate or remodel your house, then you should be sure to hire professional service providers to get the job done right. There are numerous options for licensed general contracting companies that offer wide range of such services at competitive rates.

Some of the most popular remodeling projects include:

? Kitchens

? Bathrooms

? Bedrooms

? Living Rooms

Most clients find what they are searching for from the area's leading companies, because the best businesses have multiple areas of expertise apart from Los Angeles Remodeling. These professionals will help you update and improve flooring and cabinets, and they have the services of electricians, plumbers and other experts to complete the work quickly and accurately. Experts at these companies work closely with their clients to ensure the finished project reflects the unique creativity of the homeowner.

If you are searching for a reliable Los Angeles bathroom remodeling company, visit some of the client feedback websites for recommendations. Find professionals that are experienced remodelers for all types of bathroom designs, including modern, classic, and traditional. With the help of these services, you can look forward to a beautiful, practical space in your bathroom.

Many companies provide reliable services for kitchen remodeling Los Angeles and its surrounding areas. If you are ready to create the kitchen of your dreams, choose the services of a professional, experienced remodeling company. They will make your kitchen both beautiful and functional, so you and your family can enjoy quality time while cooking and eating together. When you select a company with many years of remodeling experience, you can be confident that they understand what you want in your kitchen. Therefore, they can help create a perfect kitchen design that suits the specific needs of your lifestyle. Homeowners aren't the only ones that can benefit from quality remodeling. These services are also available for commercial buildings like hotels and restaurants, at very competitive prices.

When you look for a quality Construction Company Orange County that you can trust, these are the features that will ensure your project runs smoothly:

? More than two decades of experience

? 3D blueprint design reviewed with clients before construction/renovation begins

? High-quality, effective methods and advanced technologies

? Quality services at reasonable fees

? Guaranteed client satisfaction

Hire professional service providers and take the advantage of their ability to transform your home through remodeling and construction at affordable rates. For more information, visit them online.

Keywords: Construction company Orange County, kitchen remodeling Los Angeles, Los Angeles bathroom remodeling, Los Angeles remodeling

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Vitamin B12 deficiency: Tracking the genetic causes

Monday, August 27, 2012

Vitamin B12 is essential to human health. However, some people have inherited conditions that leave them unable to process vitamin B12. As a result they are prone to serious health problems, including developmental delay, psychosis, stroke and dementia. An international research team recently discovered a new genetic disease related to vitamin B12 deficiency by identifying a gene that is vital to the transport of vitamin into the cells of the body. This discovery will help doctors better diagnose this rare genetic disorder and open the door to new treatments. The findings are published in the journal Nature Genetics.

"We found that a second transport protein was involved in the uptake of the vitamin into the cells, thus providing evidence of another cause of hereditary vitamin B12 deficiency", said Dr. David Rosenblatt, one of the study's co-authors, scientist in medical genetics and genomics at the Research Institute of the McGill University Health Centre (RI MUHC) and Dodd Q. Chu and Family Chair in Medical Genetics and the Chair of the Department of Human Genetics at McGill University. "It is also the first description of a new genetic disease associated with how vitamin B12 is handled by the body".

These results build on previous research by the same team from the RI MUHC and McGill University, with their colleagues in Switzerland, Germany and the United States. In previous work, the researchers discovered that vitamin B12 enters our cells with help from of a specific transport protein. In this study, they were working independently with two patients showing symptoms of the cblF gene defect of vitamin B12 metabolism but without an actual defect in this gene. Their work led to the discovery of a new gene, ABCD4, associated with the transport of B12 and responsible for a new disease called cblJ combined homocystinuria and methylmalonic aciduria (cblJ-Hcy-MMA).

Using next generation sequencing of the patients' genetic information, the scientists identified two mutations in the same ABCD4 gene, in both patients. "We were also able to compensate for the genetic mutation by adding an intact ABCD4 protein to the patients' cells, thus allowing the vitamin to be properly integrated into the cells," explained Dr. Matthias Baumgartner, senior author of the study and a Professor of metabolic diseases at Zurich's University Children's Hospital.

Vitamin B12, or cobalamin, is essential for healthy functioning of the human nervous system and red blood cell synthesis. Unable to produce the vitamin itself, the human body has to obtain it from animal-based foods such as milk products, eggs, red meat, chicken, fish, and shellfish ? or vitamin supplements. Vitamin B12 is not found in vegetables.

"This discovery will lead to the early diagnosis of this serious genetic disorder and has given us new paths to explore treatment options. It also helps explain how vitamin B12 functions in the body, even for those without the disorder," said Dr. Rosenblatt who is the director of one of only two referral laboratories in the world for patients suspected of having this genetic inability to absorb vitamin B12. Dr. Rosenblatt points out that the study of patients with rare diseases is essential to the advancement of our knowledge of human biology.

###

McGill University Health Centre: http://www.muhc.ca/

Thanks to McGill University Health Centre for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/122944/Vitamin_B___deficiency__Tracking_the_genetic_causes

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Monday, August 27, 2012

Weighing molecules one at a time: Physicists create first-ever mechanical device that measures mass of single molecule

ScienceDaily (Aug. 26, 2012) ? A team led by scientists at the California Institute of Technology (Caltech) have made the first-ever mechanical device that can measure the mass of individual molecules one at a time.

This new technology, the researchers say, will eventually help doctors diagnose diseases, enable biologists to study viruses and probe the molecular machinery of cells, and even allow scientists to better measure nanoparticles and air pollution.

The team includes researchers from the Kavli Nanoscience Institute at Caltech and Commissariat ? l'Energie Atomique et aux Energies Alternatives, Laboratoire d'?lectronique des technologies de l'information (CEA-LETI) in Grenoble, France. A description of this technology, which includes nanodevices prototyped in CEA-LETI's facilities, appears in the online version of the journal Nature Nanotechnology on August 26.

The device -- which is only a couple millionths of a meter in size -- consists of a tiny, vibrating bridge-like structure. When a particle or molecule lands on the bridge, its mass changes the oscillating frequency in a way that reveals how much the particle weighs.

"As each particle comes in, we can measure its mass," says Michael Roukes, the Robert M. Abbey Professor of Physics, Applied Physics, and Bioengineering at Caltech. "Nobody's ever done this before."

The new instrument is based on a technique Roukes and his colleagues developed over the last 12 years. In work published in 2009, they showed that a bridge-like device -- called a nanoelectromechanical system (NEMS) resonator -- could indeed measure the masses of individual particles, which were sprayed onto the apparatus. The difficulty, however, was that the measured shifts in frequencies depended not only on the particle's actual mass, but also on where the particle landed. Without knowing the particle's landing site, the researchers had to analyze measurements of about 500 identical particles in order to pinpoint its mass.

But with the new and improved technique, the scientists need only one particle to make a measurement. "The critical advance that we've made in this current work is that it now allows us to weigh molecules -- one by one -- as they come in," Roukes says.

To do so, the researchers analyzed how a particle shifts the bridge's vibrating frequency. All oscillatory motion is composed of so-called vibrational modes. If the bridge just shook in the first mode, it would sway side to side, with the center of the structure moving the most. The second vibrational mode is at a higher frequency, in which half of the bridge moves sideways in one direction as the other half goes in the opposite direction, forming an oscillating S-shaped wave that spans the length of the bridge. There is a third mode, a fourth mode, and so on. Whenever the bridge oscillates, its motion can be described as a mixture of these vibrational modes.

The team found that by looking at how the first two modes change frequencies when a particle lands, they could determine the particle's mass and position, explains Mehmet Selim Hanay, a postdoctoral researcher in Roukes's lab and first author of the paper. "With each measurement we can determine the mass of the particle, which wasn't possible in mechanical structures before."

Traditionally, molecules are weighed using a method called mass spectroscopy, in which tens of millions of molecules are ionized -- so that they attain an electrical charge -- and then interact with an electromagnetic field. By analyzing this interaction, scientists can deduce the mass of the molecules.

The problem with this method is that it does not work well for more massive particles -- like proteins or viruses -- which have a harder time gaining an electrical charge. As a result, their interactions with electromagnetic fields are too weak for the instrument to make sufficiently accurate measurements.

The new device, on the other hand, does work well for large particles. In fact, the researchers say, it can be integrated with existing commercial instruments to expand their capabilities, allowing them to measure a wider range of masses.

The researchers demonstrated how their new tool works by weighing a molecule called immunoglobulin M (IgM), an antibody produced by immune cells in the blood. By weighing each molecule -- which can take on different structures with different masses in the body -- the researchers were able to count and identify the various types of IgM. Not only was this the first time a biological molecule was weighed using a nanomechanical device, but the demonstration also served as a direct step toward biomedical applications. Future instruments could be used to monitor a patient's immune system or even diagnose immunological diseases. For example, a certain ratio of IgM molecules is a signature of a type of cancer called Waldenstr?m macroglobulinemia.

In the more distant future, the new instrument could give biologists a view into the molecular machinery of a cell. Proteins drive nearly all of a cell's functions, and their specific tasks depend on what sort of molecular structures attach to them -- thereby adding more heft to the protein -- during a process called posttranslational modification. By weighing each protein in a cell at various times, biologists would now be able to get a detailed snapshot of what each protein is doing at that particular moment in time.

Another advantage of the new device is that it is made using standard, semiconductor fabrication techniques, making it easy to mass-produce. That's crucial, since instruments that are efficient enough for doctors or biologists to use will need arrays of hundreds to tens of thousands of these bridges working in parallel. "With the incorporation of the devices that are made by techniques for large-scale integration, we're well on our way to creating such instruments," Roukes says. This new technology, the researchers say, will enable the development of a new generation of mass-spectrometry instruments.

"This result demonstrates how the Alliance for Nanosystems VLSI, initiated in 2006, creates a favorable environment to carry out innovative experiments with state-of-the-art, mass-produced devices," says Laurent Malier, the director of CEA-LETI. The Alliance for Nanosystems VLSI is the name of the partnership between Caltech's Kavli Nanoscience Institute and CEA-LETI. "These devices," he says,"will enable commercial applications, thanks to cost advantage and process repeatability."

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Story Source:

The above story is reprinted from materials provided by California Institute of Technology. The original article was written by Marcus Woo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. M. S. Hanay, S. Kelber, A. K. Naik, D. Chi, S. Hentz, E. C. Bullard, E. Colinet, L. Duraffourg, M. L. Roukes. Single-protein nanomechanical mass spectrometry in real time. Nature Nanotechnology, 2012; DOI: 10.1038/nnano.2012.119

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/Pw5swZi0Sl8/120826143528.htm

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Why?s everybody so angry about Twitter ? and should you care?

22 hrs.

People have different reasons for being upset with Twitter right now, and those reasons really depend?on what type of Twitter user you are. Here are the people Twitter's changes are going to affect the most, and why?they're angry about the new rules.

The crux of why people are upset with Twitter is pretty simple: Twitter is?changing its Application Programming Interface (API)and closing off how third-party apps communicate with Twitter. For casual Twitter users, this means that Twitter controls what information apps can access on Twitter, how they access it, and how the apps shoots out the data on their ends. On the surface, the main goal is to keep Twitter clients consistent, and push ads equally throughout all of Twitter.

The Twitter developers who are worried about what the changes mean for their Business
Developers who build Twitter clients like?MetroTwit?or?TweetBot?are the most clearly affected by Twitter's new rules. In Twitter's new?API Terms, Twitter states that Twitter clients need to keep in line with Twitter's layout rules, which require tweets to be displayed in a single way, with all their buttons in the right places. From a visual point of view, all Twitter apps should essentially look the same. However, in a?blog post?back in June, Twitter also stated that developers should not, "build client apps that mimic or reproduce the mainstream Twitter consumer client experience." Essentially, this means Twitter doesn't want people building new Twitter clients.

Twitter has also instituted a user cap of 100,000 people for any app that uses the Twitter API, but they are giving a special allowance to any apps that already has over 100,000 users. When a new app gets more users that 100,000, it needs special permission from Twitter to continue on. This includes not just the Twitter clients that show your Twitter stream, but also apps that tap into the Twitter ecosystem like the aggregation tool?Storify?or the "what you did a year ago" webapp?Timehop. Essentially, if your app taps into Twitter for any reason, you're going to see changes.

From a strictly Twitter client point of view, the changes seem like they'll cut Twitter clients completely. However, in a blog post, Tweetbot developer Tapbots explains they'll?continue work their clients?(iPhone, iPad, and Mac), and the majority of the app will be unchanged. Twitterific developer Icon Factory?says the same thing.

Not all developers are so confident, and?several have sent letters to the FTC?requesting an investigation into possible antitrust issues that arise by Twitter forcing other apps out of the game.

Until we see how Twitter enforces these rules it's difficult to know exactly what to expect.

The Twitter power users who like third-party utilities

Twitter power users are going to see big changes in their Twitter clients, but many of the analytics tools they use will remain untouched. In fact, in Twitter's?blog post?on the issue, they specifically high-five the likes of?Crimson Hexagon,?Topsy,?Hootsuite, and others. In short, if you're using apps that are targeted at businesses, for data mining or otherwise, you're probably fine.

However, power users will likely see less customized clients built specifically for certain types of users. Lifehacker founder Gina Trapani sums it up on the?In Beta podcast:

I think the big thing people are upset about is that we're going to see fewer custom power user clients. Which really sucks for the power user who want the very specialized client who lets you mute keywords, or whatever.

The reason? With a new rules, developers might not put forth the effort to build specialized clients anymore. It could also mean that currently beloved clients will just give up. It's no fun playing in a playground with chains and locks on all the equipment. Since this hinges on how developers react, it's hard to judge exactly what the effect will be until Twitter starts enforcing these rules.

Twitter users who like services like Flipboard that plug into Twitter

The loudest outrage from most people is how Twitter's been tackling the way third-party services access Twitter. In a tiny way, this is about how?Tumblr, Instagram, and LinkedIn?users can't search for friends on Twitter any more.

More worrisome about the new API rules is how it might restrict apps like the popular social news app?Flipboard, which accesses tweets, but isn't a client itself. The worry comes from Rule 5a of the?Timeline display guide:

Tweets that are grouped together into a timeline should not be rendered with non-Twitter contents. Eg comments, updates from other networks.

Instapaper developer Marco Arment?talks about why this might matter in a blog post:

In other words, apps cannot interleave chronological groups of Twitter posts with anything else.

This is very broad and will bite more services and apps than you may expect. It's probably the clause that caused the dispute with LinkedIn, and why Flipboard CEO Mike McCue just left Twitter's board.

Closer to home for me, it affects Instapaper's "Liked By Friends" browsing feature, which will need to be significantly rewritten if I want it to comply. (If.)

Essentially, services that tap into your Twitter feed and regurgitate links into a new visual style could be blocked. This means magazine-style browsing apps like Flipboard?could?be cut off.

The likely reasoning from Twitter's point of view is simple. When you access links from who you follow on Twitter without ever going to Twitter itself, you can get the Twitter experience without ever looking at advertisements.

The optimistic Web nerds who want Twitter to be a platform, not a media company
When Twitter first launched, it was a wide-open, easy-to-develop-for platform that felt something like the wild wild west of internet communication. Now, Twitter is closing in on itself, and changing its overall approach from open platform for communication to media company. The reason? Money. (They're a for-profit company, so while the results are frustrating, it's silly to blame them for this.)?The Verge lays it out like so:

Creating a platform like Twitter is impossibly hard, but after years of fail whales, the company pulled it off. Monetizing a platform is harder still, and it looks like Twitter has taken the easier path: monetizing its social graph without sharing the wealth with the developers who helped build it.

The reason the social graph (who you follow/who follows you) is important from an advertising point of view is pretty simple: people use Twitter like they use a TV, they follow who they're interested in and that reflects a marketing potential. This makes direct advertising easy.

Twitter's original API was wide open, and out of it sprung all types of innovative apps and uses?the very same things that turned Twitter into the successful company it is today. The openness was the exact reason many of us started using the service in the first place. Twitter was a platform you could access in a variety of ways, and use for a number of different reasons. You could track celebrities, communicate with people, and share links with complete strangers. Users wanted to think of it as a platform similar to email as opposed to a media company (like Facebook). It's easy to see that Twitter needs to make money, but many people hoped (perhaps naively) that Twitter would still function as a platform. Not as yet another Facebook.

So, should you care?

Twitter's guidelines for some of these changes are still pretty vague, and interpretations of how Twitter will implement the changes are all over the place. Developers have six months to comply with the new API, and hopefully by then we'll have a better idea of how it's going to affect everyone.

So, should you care? That depends on how you use Twitter. The issues above effect different people in different ways, but even the casual user will see restrictions with the apps and clients they use.

More from Lifehacker

Source: http://www.nbcnews.com/technology/technolog/whys-everybody-so-angry-about-twitter-should-you-care-965306

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TelcoDepot.com Introduces Expanded Range of Conference Phone ...

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TelcoDepot.com has launched an expanded range of conference phone equipment and accessories on its online phone system store. TelcoDepot.com is a provider of business phone system equipment and services covering VoIP phones, VoIP service, hosted PBX service, PBX phone system equipment, telephone system accessories (such as phone headset units and more) and VoIP phone system support. Shop for leading business phones and equipment from brands like Aastra, Allworx, Grandstream, NEC phone system products, TalkSwitch, Xblue and Yealink at affordable prices with great support options.

Conferencing systems are essential for the survival of modern businesses ? remote workers, decentralized operations, distributed workspaces and workflow processing, outsourcing and other modern business concepts require some sort of organized central communications structure ? and this is what real-time multi-party conferencing provides.

TelcoDepot.com now provides businesses with an expanded range of award-winning conference phone solutions and accessories including;

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Businesses can also inquire about the Polycom SoundStation IP 6000 with Power supply, Polycom SoundStation IP 5000 (with optional power supply), ClearOne Max IP (SIP-based conferencing phone for small to medium conference room), ClearOne Max Wireless (wireless conference phone for movement up to 150ft from base unit), ClearOne Max EX (connect to analog line or station port of any phone system), Jabra SPEAK 410 (USB VoIP desktop hands-free speakerphone), and the ClearOne Max IP Response Point (tabletop conferencing phone - connects easily to the Microsoft Response Point phone system).

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Discounts may be available on some models; businesses are advised to inquire with TelcoDepot.com customer service.

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To learn more about the TelcoDepot.com conferencing systems and accessories, including available systems, configuration options and pricing, visit http://www.telcodepot.com/telephones/conference-phone. For additional inquiries, call TelcoDepot.com support lines on 1-800-390-1200 or send an email to info@telcodepot.com.

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Source: http://www.freeprnow.com/pr/telcodepot.com-introduces-expanded-range-of-conference-phone-systems

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Sunday, August 26, 2012

Cuba campaign takes on 'free' health care

In this Aug 10, 2012 photo, a nurse gives Karolin Deniss Verdecia a shot for allergies at a government run neighborhood clinic in Havana, Cuba. Cuba's system of free medical care, long considered a birthright by its citizens and trumpeted as one of the communist government's great successes, is not immune to cutbacks under Raul Castro's drive for efficiency. The health sector has already endured millions of dollars in budget cuts and tens of thousands of layoffs, and Castro is looking for more ways to save. (AP Photo/Franklin Reyes)

In this Aug 10, 2012 photo, a nurse gives Karolin Deniss Verdecia a shot for allergies at a government run neighborhood clinic in Havana, Cuba. Cuba's system of free medical care, long considered a birthright by its citizens and trumpeted as one of the communist government's great successes, is not immune to cutbacks under Raul Castro's drive for efficiency. The health sector has already endured millions of dollars in budget cuts and tens of thousands of layoffs, and Castro is looking for more ways to save. (AP Photo/Franklin Reyes)

In this Aug 13, 2012 photo, a sick man is taken by ambulance to the public hospital Calixto Garcia in Havana, Cuba. Cuba's system of free medical care, long considered a birthright by its citizens and trumpeted as one of the communist government's great successes, is not immune to cutbacks under Raul Castro's drive for efficiency. The health sector has already endured millions of dollars in budget cuts and tens of thousands of layoffs, and Castro is looking for more ways to save. (AP Photo/Franklin Reyes)

In this Aug 13, 2012 photo, a lab technician takes a blood sample for testing at the government run community Medical Clinic Robert Zulueta in Havana, Cuba. Cuba's system of free medical care, long considered a birthright by its citizens and trumpeted as one of the communist government's great successes, is not immune to cutbacks under Raul Castro's drive for efficiency. The health sector has already endured millions of dollars in budget cuts and tens of thousands of layoffs, and Castro is looking for more ways to save. (AP Photo/Franklin Reyes)

In this Aug 16, 2012 photo, a nurse checks the blood pressure of patient Niurka Rodriguez, who is eight months pregnant at a government run neighborhood clinic in Havana, Cuba. Cuba's system of free medical care, long considered a birthright by its citizens and trumpeted as one of the communist government's great successes, is not immune to cutbacks under Raul Castro's drive for efficiency. The health sector has already endured millions of dollars in budget cuts and tens of thousands of layoffs, and Castro is looking for more ways to save. (AP Photo/Franklin Reyes)

In this Aug 16, 2012 photo, a poster that reads in Spanish "Your service is free health... but it costs" hangs on a wall inside a government run neighborhood clinic in Havana, Cuba. Cuba's system of free medical care, long considered a birthright by its citizens and trumpeted as one of the communist government's great successes, is not immune to cutbacks under Raul Castro's drive for efficiency. The health sector has already endured millions of dollars in budget cuts and tens of thousands of layoffs, and Castro is looking for more ways to save. (AP Photo/Franklin Reyes)

(AP) ? Cuba's system of free medical care, long considered a birthright by its citizens and trumpeted as one of the communist government's great successes, is not immune to cutbacks under Raul Castro's drive for efficiency.

The health sector has already endured millions of dollars in budget cuts and tens of thousands of layoffs, and it became clear this month that Castro is looking for more ways to save when the newspaper voice of the Communist Party, Granma, published daily details for two weeks on how much the government spends on everything from anesthetics and acupuncture to orthodontics and organ transplants.

It's part of a wider media campaign that seems geared to discourage frivolous use of medical services, to explain or blunt fears of a drop-off in care and to remind Cubans to be grateful that health care is still free despite persistent economic woes. But it's also raising the eyebrows of outside analysts, who predict further cuts or significant changes to what has been a pillar of the socialist system implanted after the 1959 revolution.

"Very often the media has been a leading indicator of where the economic reforms are going," said Phil Peters, a longtime Cuba observer at the Lexington Institute think tank. "My guess is that there's some kind of policy statement to follow, because that's been the pattern."

The theme of the Granma pieces, posters in clinics and ads on state TV is the same: "Your health care is free, but how much does it cost?"

The answer is, not much by outside standards, but quite a bit for Cuba, which spends $190 million a year paying for its citizens' medical bills.

Based on the official exchange rate, the government spends $2 each time a Cuban visits a family doctor, $4.14 for each X-ray and $6,827 for a heart transplant.

It's not a luxury service though. Scarcities now are common and sanitary conditions fall short of the ideal in decaying facilities where paint peels from the walls. Patients often bring their own bed sheets, electric fans, food and water for hospital stays.

One Havana-based clinical physician applauded the campaign, saying it targets a pervasive problem: Conditioned to think about health as an inalienable right, many Cubans rush to the hospital whenever they come down with a cough or the sniffles, demand expensive tests before they've even been examined and sometimes get aggressive if doctors refuse.

"Respect for doctors has entirely been lost," he said. "Some will indulge a patient for fear of how they might react."

The physician spoke on condition of anonymity because he was not authorized to discuss health care with a foreign journalist. Interview requests were not granted by the Health Ministry, though a spokeswoman said in a brief email response that the costs in Granma were the result of careful study.

The fact that the figures were published at all suggests a sea change in conceptions about health care, said Nancy Burke, director of the Cuba Program in Health Diplomacy at the University of California, San Francisco.

"It's interesting that the health care system, which has always been touted as a basic human right, is now being put into market terms," said Burke, a medical anthropologist who makes yearly research trips to Cuba. "That says so much about Raul's market reforms and the ideology ... informing that. It's a real shift, a major shift in the way of thinking about health care."

She noted that the island's doctors are increasingly cash cows for Cuba as it sends them abroad to treat the poor in countries such as Venezuela. The international missions fulfill a humanitarian purpose but also offset a significant share of the $28.5 billion in cash and subsidized oil that the South American nation has sent Cuba since 2005, according to Venezuelan opposition lawmaker Julio Borges, who says he uses public records to track the figure.

To cut costs in Cuba, state media have urged doctors to use their "clinical eye" before ordering pricey lab tests, and target the practice of people stockpiling medicine to carry them through shortages.

In one TV spot, a woman visits a doctor and requests a long list of pills. Asked why she needs so many, she replies: "Oh, doctor, it's for my personal stash."

"I stop cold when I see that, not knowing whether to laugh or cry," blogger Greter Torres Vazquez wrote on a Cuban youth-issues website. "Maybe they've never had the experience of going to the pharmacy and asking for medicine that their aunt, their grandmother, their mother needs urgently, only for the worker to say 'Sorry, we ran out five minutes ago.'"

Some seized on the campaign to complain about corruption in hospitals.

"They should also publish the miserable salary that doctors get paid; that's an embarrassment," said Maria Soto, a 62-year-old Havana resident. "And it's serious, because it leads to the problems everyone knows about: You get bad service or, even worse, they charge you under the table."

Cuban authorities continuously brag about keeping health care free and universal despite its lightweight economy and the 50-year-old U.S. embargo.

Experts credit the government's emphasis on prevention and doctor-patient relationships for life expectancy and infant mortality rates that are on par with those of wealthy nations. Medical schools churn out huge graduating classes; every last one of Cuba's 11 million citizens is supposed to get a house call at least once a year.

Charging for care would be a dramatic and unlikely about-face, but with 15 percent of the budget devoted to health, Havana sees no choice but to make the system more efficient wherever it can.

After steadily rising over five decades to hit $206 million in 2009, health spending has dropped, slipping to $190 million last year, according to government figures. Officials hint at more cuts to come.

These days, authorities rail against "irrational expenses" and have slashed more than 50,000 less-skilled health-sector jobs, singling out overstaffed clinics and ambulances with multiple drivers.

Some Cubans say hospital wait times seem to be on the rise and medicine, equipment and soap are increasingly in short supply.

The clinical doctor consulted by the AP said neither scarcity nor complaints have worsened, though doctors still suffer heavy case loads and low pay, about $25 a month.

Cuba is walking a delicate line on health: Too much change could be seen in some camps as a betrayal of the socialist contract. Too little may not ease the burden on a strained economy, said Sergio Diaz-Briquets, a U.S.-based demographer and author of "The Health Revolution in Cuba.

"It is maybe a universal phenomenon that health care systems are expensive," he said, "but Cuba perhaps cannot afford to have the kind of services that they claim to have had in the past."

___

Associated Press writers Andrea Rodriguez and Anne-Marie Garcia contributed to this report.

___

Peter Orsi on Twitter: www.twitter.com/Peter_Orsi

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2012-08-25-Cuba-Shrinking%20Health%20Care/id-02b5685c69f6474398f2122ab8bc036f

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Poll finds swath of voters undecided, unexcited

WASHINGTON (AP) ? Call them maybes.

Two months out from Election Day, nearly a quarter of all registered voters are either undecided about the presidential race or iffy in their support for a candidate, an Associated Press-GfK poll shows.

These voters could well prove decisive in a close contest. And they will be tough nuts for Barack Obama and Mitt Romney to crack.

Just 29 percent of them have a strong interest in the campaign, compared with 51 percent of those who've made up their minds. So no, they won't be hanging on every word coming out of the national political conventions in Tampa, Fla., and Charlotte, N.C., over the next two weeks.

Who are they? These so-called persuadable voters are more often men than women. They are a bit younger than those who've made up their minds. They have less education and income. And they are far less partisan.

A quarter are independent or unaffiliated, while more than a third consider themselves Democrats and a similar share count themselves as Republicans.

They are folks like Eric Avila, a 35-year-old Democrat from Tampa who didn't vote in 2008, has been unemployed since he was laid off from a sales job four years ago and doubts that either candidate will do much to reduce joblessness.

Avila plans to vote this time but finds the campaign rhetoric from both sides grating. "It kind of gets on your nerves after a while," he says, "all of this stuff a person's promising, and it just gets forgotten or buried under a whole bunch of other things."

Take that, Barack and Mitt. Their challenge is to figure out what will shift people like Avila firmly one way or the other.

Ask the persuadables what will be the single most important factor in deciding their vote, and they have a multitude of answers at the ready.

"Whoever runs the cleanest campaign," says one of those surveyed.

"Whoever has the dirtiest ad campaigns on TV," counters another.

A third, who speaks for many, confesses she has "no idea" what will win her over.

How the persuadables ultimately vote could hinge on which issues rise to the top of the campaign.

Romney holds the advantage among these voters on the economy, creating jobs and the federal budget deficit. But on two issues that have recently grabbed the spotlight ? social issues and Medicare ? Obama is the more trusted candidate among these voters.

Neither Obama nor Romney carries much weight with the persuadables, though: Half have an unfavorable opinion of each candidate.

Count Pam Zickert, an independent from Santa Maria, Calif., among those who are undecided and unenthusiastic.

The 62-year-old retiree dislikes Obama, finds Romney "a bit bland" and has no intention of watching the political conventions.

"It's tough to pick a presidential candidate when none of them are inspiring," says Zickert, who voted for Republican John McCain in 2008.

William Galston, an expert on government and politics at the Brookings Institution and a former Clinton administration official, says that because the persuadables are more difficult to win over, Obama and Romney so far have been more focused on firming up support among their base supporters than on cultivating those on the fence.

Romney's selection of conservative darling Rep. Paul Ryan as a running mate was "a decision to place mobilization ahead of persuasion," he says, and Obama's campaign has been systematically targeting the basic building blocks of his winning 2008 coalition: women, Hispanics, younger voters and gays and lesbians among them.

In a polarized political environment and with limited dollars to spend, says Galston, "you can increase your vote total much more per dollar by ginning up the enthusiasm of the people who are already for you."

Still, in a tight race, the persuadables could ultimately make the difference in key swing states, and they can't be ignored. The campaigns may well spend the convention weeks and September firming up their base supporters, then devote the debates and the final weeks of the race to reaching out to more fickle persuadables.

In the AP-GfK survey, taken Aug. 16-20, the 23 percent of registered voters who are considered persuadable included 7 percent who expressed no presidential preference, 7 percent with soft support for Obama and 9 percent with soft support for Romney. The poll involved landline and cellphone interviews with 885 registered voters, including 192 considered persuadable. The margin of sampling error for registered voters was plus or minus 4.1 percent, and for persuadables 8.9 points.

Will the persuadables actually show up and vote? History suggests yes.

In an AP-Yahoo study that interviewed the same people multiple times over the course of the 2008 presidential campaign, 38 percent of registered voters were persuadable in interviews conducted just ahead of that year's conventions. When that same group was interviewed on Election Day, three-fourths said they had voted.

When will the undecideds make up their minds?

In 2004 and 2008, about 10 percent of voters reported they didn't decide until the last week, according to exit polls.

Michelle Woodby, a 36-year-old Republican homemaker from Tecumseh, Mich., says she's been known to wait until the last minute.

With small kids to care for and little time to watch the news, Woodby says she hasn't fully tuned in yet.

So far, Romney's opposition to abortion has won her over, but Woodby says she's still got a lot of studying to do ? and she shows a decided lack of enthusiasm for the job.

"I need to do my homework," she says, "which I dread."

___

Online: http://www.ap-gfkpoll.com

___

Associated Press writer Josh Lederman and AP News Survey Specialist Dennis Junius contributed to this report.

Source: http://news.yahoo.com/poll-finds-swath-voters-undecided-unexcited-145751143.html

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Self Improvement & Memory Training: Ways to Improve Your Self ...

ByAnthony O Kamson

Confidence - what is it and how do we attain it?

"I see myself falling flat on my face and then I do". Is a common statement by those who have come to believe that they 'lack confidence'

What you think will happen. If you think you're a failure, you will fail. Confident people think themselves successful and they find success, even though their confidence is most of the time an act. They literally run a kind of internal home movie where they are doing well.

So, before something nerve-wracking happens run through a positive internal 'home movie' of yourself in the situation that you are in. If you're going for a job interview, imagine just how well you'll do and tell yourself you're going to succeed. Even if you don't get the job, you'll naturally do better than if you had imagined the worst.

"I typically feel so nervous inside that I sabotage myself as though stage-fright". What are sometimes called 'butterflies' are useful. They in fact remind us to give our very best performance. However, they can also make us so physically nervous that we fail. The answer is simple; by faking it, you can often end up feeling confident quite naturally. This is what people do who appear confident do on a daily basis.

So just before that important task or that big date, relax, then stand tall, hold your head up, relax your shoulders and stand with your weight evenly balanced over each foot smile to raise your spirits and go for it!

"However good I feel, I often look nervous to other people". If you act as though you lack confidence, other people will react to that. Often badly. Use the 'SET' plan, smile, eye contact, touch. All which pick up on the three elements confident people typically demonstrate.

1. Smile and you'll seem relaxed.
2. Hold eye contact and you'll seem sure of yourself.
3. Touch with a firm handshake and you'll seem in control.

"I sometimes feel unsure when I'm doing something new". This statement sounds really negative. Isn't it bad to feel unsure? But actually, this is a positive strategy in some new circumstances. It's no good feeling falsely sure of yourself in all new things. If you were too confident you may not see a potential danger.

With anything new, feeling unconfident is your mind's way of alerting you to your lack of experience or a potential danger. So this isn't a negative thought pattern. But you may have wrongly viewed it as negative. And your reaction to the new situation was wrong.

So with anything new a speech, an interview, any new skill, practice ahead of time is what is needed. By rehearsing you will raise your performance and in turn raise your confidence. Through hypnosis you rehearse different situations as if they were real and you do this within you own mind. This speeds up the learning process in gaining more confidence.

Self Hypnosis: If you are interested in self hypnosis and would like me to send you a free personally tailored script which you can use to help you, a family member, partner, or friend gain more confidence visit my website and send me an email. And if you have a website why not add a link to my website so that others may benefit from this unique service. http://www.hypnosolutionsmanchester.co.uk

Article Source:http://EzineArticles.com/?expert

Source: http://selfimprovementandmemorytraining.blogspot.com/2012/08/ways-to-improve-your-self-confidence.html

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Saturday, August 25, 2012

Bigger creatures live longer, travel farther for a reason

ScienceDaily (Aug. 24, 2012) ? A long-standing mystery in biology about the longer lifespans of bigger creatures may be explained by the application of a physical law called the Constructal Law.*

What this law proposes is that anything that flows -- a river, bloodstream or highway network -- will evolve toward the same basic configuration out of a need to be more efficient. And, as it turns out, that same basic law applies to all bodies in motion, be they animals or tanker trucks, says Adrian Bejan, the J.A. Jones Professor of mechanical engineering at Duke and father of the Constructal Law.

In his latest theory paper, appearing Aug. 24 in the journal Nature Scientific Reports, Bejan argues that there is a universal tendency for larger things, animate and inanimate, to live longer and to travel further.

He starts his argument with an examination of the well-known observation in biology that larger animals tend to live longer. Bejan wanted to see if this general rule might apply to inanimate systems as well and proceeded to mathematically analyze the relationship in rivers, jets of air and vehicles.

He found, as a general rule, that bigger rivers are older and that larger jets of air, such as atmospheric jet streams, last longer. By his calculations, larger vehicles should also last longer, but hard evidence of that is lacking, he says, and there are outliers of course, like Subaru Justys with 300,000 miles.

By being larger and lasting longer, all of these systems also travel farther, he says.

If you look at a moving vehicle or animal simply as a mass in motion, that is, something flowing, "the spreading of the mass of vehicles and animals is completely analogous to the flow of water in river channels," Bejan says. "It is the same design."

Interestingly, if the body size and lifespan of known species of animals are plotted on a curve, it falls on a slope of about ?. And then, following a different line of inquiry, if you plot the frequency of breathing to body size, that is a slope of - ?.

When combined, these two insights about animal body size work out to a constant for the number of breaths per lifetime, Bejan says. This gives most creatures about the same number of breaths in their lifetime, but the larger, slower-breathing animals use their breaths up over a longer span of time. "So bigger means a longer lifespan," he said. "I was looking at this enigma about body size and longevity from a point of view that hadn't occurred to biologists," Bejan said.

The Constructal Law governs how big an engine a truck needs and how big a heart a whale needs. "There's no difference between a vehicle and an animal," Bejan said. "Being larger means two things, not one: you live longer and you travel farther."

There are, of course, notable exceptions to the rule: The 4-ounce Arctic Tern travels more than 44,000 miles a year.

"The size-effect on travel and life time is the same for the animate and the inanimate," Bejan argues. "Everything that moves enjoys the same design."

* www.constructal.org.

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The above story is reprinted from materials provided by Duke University, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Adrian Bejan. Why the bigger live longer and travel farther: animals, vehicles, rivers and the winds. Scientific Reports, 2012; 2 DOI: 10.1038/srep00594

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/jqHofVmPcIc/120824082532.htm

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TheYoungTurks: #BigOil donated more than $1 million to @MittRomney, & now Romney's energy plan champions drilling everywhere http://t.co/lL17eaeO

Sorry, Readability was unable to parse this page for content.

Source: http://twitter.com/TheYoungTurks/statuses/238825487403712513

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Canada economic growth again seen below forecasts

OTTAWA (Reuters) - Canada's economy likely grew at a disappointing pace for the third straight time in the second quarter, expanding at a slower rate than the Bank of Canada expects and adding the country's unused productive capacity.

In a Reuters survey of analysts on Friday, the median estimate was for annualized growth of 1.6 percent, not enough to absorb the slack in the economy. Such a pace is likely to keep the central bank from raising interest rates anytime soon.

The Bank of Canada reckons that the economy's potential output grows by 2 percent a year. Anything less than that adds to unused capacity and in theory reduces inflationary pressure.

In July the bank said it expected second-quarter growth of 1.8 percent, a downward revision from its previous forecast of 2.5 percent. Canada will miss the lower forecast if the economists are correct.

Only four of 23 economists in the Reuters survey saw growth of at least 1.8 percent. Growth in the previous two quarters was 1.9 percent, and it undershot the Bank of Canada's forecast by as much as 0.6 points in the first quarter.

For June, the economists saw minimal growth of 0.1 percent, repeating May's result after a 0.3 percent figure in April.

Weak net exports took the greatest toll on second-quarter economic growth, with the trade surplus shifting from an C$80 million ($80.6 million) surplus in March to a C$1.81 billion deficit by June, due to lower oil prices as well as higher imports.

Consumer spending, a primary source of strength, also flagged. Retail sales dropped in April and June.

That said, Bank of Montreal senior economist Michael Gregory expects to see solid business capital spending as well as residential investment. The housing market is showing signs of cooling but lots of construction is in the pipeline.

Bank of Canada Governor Mark Carney has retained his bias towards increasing interest rates, saying this week that the underlying momentum was roughly in line with the growth in potential.

($1 = 0.9924 Canadian dollars)

(Reporting by Randall Palmer; Editing by Frank McGurty)

Source: http://news.yahoo.com/canada-economic-growth-again-seen-below-forecasts-200251816--business.html

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Friday, August 24, 2012

Zipcar partners with Houston to push EV, hybrid use

23 Aug 2012

US car sharing network Zipcar has partnered with the city of Houston to launch a municipal electric vehicle (EV) share programme.

The Houston Fleet Share initiative will use Zipcar?s technology to make 25 Nissan Leaf vehicles available to city employees across all departments.

It is funded by the State Energy Conservation Office, as part of the Recovery and Reinvestment Act.

In addition to the EVs on offer, the city has the third-largest municipal hybrid fleet in the US, with around 50 per cent of light duty vehicles already replaced by hybrids.

The partnership with Zipcar is aimed at increasing the use of these vehicles, and the Nissan EVs, as well as helping to reduce costs and gain new efficiencies in the city fleet.

Annise Parker, Mayor of Houston, said, ?Houston is setting the pace for sustainability efforts and we are very proud to be working with Zipcar to launch the nation?s first-ever municipal EV green fleet sharing programme.

?Although we?ve always been known as the oil capital of the world, we?re gaining momentum on being the energy capital through programs like Houston Fleet Share and the Houston Drives Electric initiative.?

Scott Griffith, Zipcar chairman and CEO, added, ?I would like to applaud Mayor Parker and the city of Houston for all the work they have done to make the city?s municipal fleet one of the most sustainable in the country through their dedication to EVs and hybrid vehicles.

?We?re excited to help make this programme even more efficient with the addition of Zipcar technology into these vehicles. By utilising Zipcar?s FastFleet technology through the new Fleet Share programme, the city of Houston joins smart city governments focused on developing solutions to complex transportation challenges.?

Copyright ? 2012 NewNet

Tags: electric vehicles, EV, green transportation, hybrid vehicles, sustainable transport


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Source: http://www.newenergyworldnetwork.com/investor-news/renewable-energy-news/by-region/north-america/zipcar-partners-with-houston-to-push-ev-hybrid-use.html

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